Hyperkeratotic dermis of anal canal

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The majority of anal neoplastic pathology encountered in day-after-day practice revolves around the diagnosing of squamous carcinoma and its precursors, even though such tumors are comparatively rare. Resection specimens are rarer still because most cancers are treated with radiation and chemotherapy. As such, biopsy diagnosing is particularly important.
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Anus | Abdominal Key

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Epidermal and Hair Follicle Tumors - Integumentary System - Merck Veterinary Manual

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For a discussion of papillomas (viral warts), the most common, viral-induced neoplasms of the skin, see Papillomas. Benign, proliferative lesions not associated with papilloma virus infection can soul a gross morphology similar to that of papillomas. Epidermal hamartomas (nevi) are rare proliferations identified only in dogs, most often in the young. Grossly, epidermal nevi appear as pigmented, hyperkeratotic, vaguely papillated papules and plaques that are occasionally arranged in a linear pattern.
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